Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.

@article{Bessero2010RoleOT,
  title={Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.},
  author={Anne-Caroline Bessero and Florence Chiodini and Elisabeth Rungger-Br{\"a}ndle and Christophe Bonny and Peter G. H. Clarke},
  journal={Journal of neurochemistry},
  year={2010},
  volume={113 5},
  pages={1307-18}
}
Retinal excitotoxicity is associated with retinal ischemia, and with glaucomatous and traumatic optic neuropathy. The present study investigates the role of c-Jun N-terminal kinase (JNK) activation in NMDA-mediated retinal excitotoxicity and determines whether neuroprotection can be obtained with the JNK pathway inhibitor, D-form of JNK-inhibitor 1 (D-JNKI-1). Young adult rats received intravitreal injections of 20 nmol NMDA, which caused extensive neuronal death in the inner nuclear and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Subconjunctival injection of XG-102, a JNK inhibitor peptide, in patients with intraocular inflammation: a safety and tolerability study.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 2015

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Short and long term axotomy-induced ERG changes in albino and pigmented rats

L. Alarcon-Martinez, V. de l, +3 authors M. Vidal-Sanz
2009
View 14 Excerpts
Highly Influenced

Specific pathophysiological functions of JNK isoforms in the brain.

The European journal of neuroscience • 2005
View 2 Excerpts

Similar Papers

Loading similar papers…