Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats.

Abstract

This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of… (More)

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