Role of the aryl hydrocarbon receptor in drug metabolism.

@article{Ramadoss2005RoleOT,
  title={Role of the aryl hydrocarbon receptor in drug metabolism.},
  author={Preeti Ramadoss and Craig H Marcus and Gary H. Perdew},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2005},
  volume={1 1},
  pages={9-21}
}
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that regulates the transcription of certain key enzymes involved in the metabolism of xenobiotic substances including some drugs. The AhR can be activated by a wide range of classes of compounds (e.g. polycyclic aromatic hydrocarbons, benzimidazoles and flavonoids), and interacts with a number of other proteins, including nuclear hormone receptors such as the oestrogen and androgen receptors. Activation of the AhR… CONTINUE READING
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