Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs.

@article{Chaudieu1989RoleOT,
  title={Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs.},
  author={Isabelle Chaudieu and Jacques Vignon and M Chicheportiche and Jean Marc Kamenka and G Trouiller and R Chicheportiche},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={32 3},
  pages={699-705}
}
Thirty-seven arylcyclohexylamines including phencyclidine (PCP) and derivatives, N[1-(2-thienyl)cyclohexyl]piperidine (TCP) and derivatives and N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) were assessed for their ability to inhibit [3H]PCP binding and [3H]dopamine ([3H]DA) synaptosomal uptake. Their pharmacological property (ataxia) was measured by means of the rotarod test. A very good correlation was observed between the inhibition of [3H]PCP binding and the [3H]DA uptake only for… CONTINUE READING

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The multiple binding sites of [~H]PCP and ['~H]TCP in the rat and human CNS

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1 Excerpt

Comparison entre les sites de fixation

  • I. Chaudieu, J. Vignon, M. Chicheportiche, A. El Harfi, J.-M. Kamenka, R. Chicheportiche
  • de la ['~H]PCP et de la [~H]TCP dans le SNC de…
  • 1987
2 Excerpts

Comparison entre les sites de fixation de la [ ' ~ H ] PCP et de la [ ~ H ] TCP dans le SNC de rat

  • I. Chaudieu, J. Vignon, M. Chicheportiche, A. El Harfi, J.-M. Kamenka, R. Chicheportiche
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