Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs

@article{Chaudieu1989RoleOT,
  title={Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs},
  author={Isabelle Chaudieu and Jacques Vignon and Mich{\`e}le Chicheportiche and Jean Marc Kamenka and G{\'e}rard Trouiller and Robert Rubin Chicheportiche},
  journal={Pharmacology Biochemistry and Behavior},
  year={1989},
  volume={32},
  pages={699-705}
}

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References

SHOWING 1-10 OF 55 REFERENCES
Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives.
TLDR
The most characteristic effects of hydroxylation of PCP on the cyclohexyl, piperidine, or phenyl moieties are the following: it generally decreases its activity in inhibiting [3H]PCP binding by a factor of 10 to 80, and it does not produce a large variation in the affinity for the morphine receptor.
A comparison between classes of drugs having phencyclidine-like behavioral properties on dopamine efflux in vitro and dopamine metabolism in vivo.
TLDR
In vivo it was found that PCP, m-amino-PCP and PCE significantly elevated HAL-induced DA metabolism, whereas ketamine and m-nitro- PCP were without effect, and both levoxadrol and EKC significantly decreased the ratio of HVA/DA after HAL administration.
Effects of phencyclidine (PCP)-like drugs on turning behavior, 3H-dopamine uptake, and 3H-PCP binding
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
  • L. Snell, K. Johnson
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1985
TLDR
It is concluded that turning is the result of nondopaminergic properties of the PCP-like drugs, based on previously reported studies of the dopaminergic Properties of these drugs.
Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes.
TLDR
PCP is less potent than amphetamine at releasing dopamine and may affect dopamine metabolism in the striatum primarily by inhibiting the reuptake of this catecholamine.
Specific [3H]phencyclidine binding in rat central nervous system.
  • S. Zukin, R. Zukin
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1979
TLDR
[3H]PCP binding was most enriched in crude synaptosomal subcellular fractions, and was about three times higher in hippocampus than in cervical spinal cord, suggesting that PCP may exert its effects on the central nervous system via binding to specific brain receptor sites.
Binding characteristics of the dopamine uptake inhibitor [3H]nomifensine to striatal membranes.
...
...