Role of the area postrema in the modulation of the baroreflex control of heart rate by angiotensin II.

@article{Matsukawa1990RoleOT,
  title={Role of the area postrema in the modulation of the baroreflex control of heart rate by angiotensin II.},
  author={Shigeaki Matsukawa and Ian A. Reid},
  journal={Circulation research},
  year={1990},
  volume={67 6},
  pages={1462-73}
}
During angiotensin II (Ang II)-induced elevation of arterial pressure, there is an attenuation of the baroreflex control of heart rate (HR), but the site of this action of Ang II on the baroreflex is not known. To investigate the role of the area postrema, the effects of Ang II on arterial pressure and HR and on the baroreflex control of HR were compared in intact and area postrema-lesioned conscious rabbits. In intact rabbits, infusion of Ang II (2.5-100 ng/kg/min) produced dose-related… CONTINUE READING