Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2.

@article{Kawaguchi1993RoleOT,
  title={Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2.},
  author={Shin-ya Kawaguchi and Martin E. Hemler},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 22},
  pages={16279-85}
}
To investigate the role of the alpha subunit cytoplasmic domain in the regulation of VLA-2 functional activity, we expressed several chimeric and deleted forms of the alpha 2 subunit in two different human cell lines, K562 and RD. Each mutant construct formed surface VLA-2 heterodimers as efficiently as wild type alpha 2 subunit, except for a construct (X2CO1127) truncated just before the consensus GFFKR cytoplasmic domain motif, that was not expressed at the cell surface. Truncation of the… CONTINUE READING

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