Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro.

@article{Xue2001RoleOT,
  title={Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro.},
  author={Hong-li Xue and Amha Atakilit and Weiying Zhu and Xiaohong Li and Daniel M. Ramos and Robert Pytela},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={288 3},
  pages={610-8}
}
Expression of the alpha(v)beta6 integrin is strikingly upregulated in several types of carcinoma, including human oral squamous cell carcinoma (SCC). Employing a neutralizing monoclonal antibody to alpha(v)beta6, we investigated its role in cell adhesion, proliferation, migration, and in vivo growth of an invasive human SCC line, termed HSC-3. We found that alpha(v)beta6 is strictly required for HSC-3 cell growth in a three-dimensional collagen gel and also prominently contributes to cell… CONTINUE READING