Role of the aggregation factor in the regulation of phosphoinositide metabolism in sponges. Possible consequences on calcium efflux and on mitogenesis.

@article{Mller1987RoleOT,
  title={Role of the aggregation factor in the regulation of phosphoinositide metabolism in sponges. Possible consequences on calcium efflux and on mitogenesis.},
  author={Werner E. G. M{\"u}ller and Matthias Rottmann and B{\"a}rbel Diehl-seifert and Branko Kurelec and G G Uhlenbruck and Heinz C. Schr{\"o}der},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 20},
  pages={9850-8}
}
The aggregation factor (AF) of the marine sponge Geodia cydonium recognizes the aggregation receptor (AR) which is inserted in the plasma membrane, under formation of species-specific aggregates. The specific cell-binding fragment of the AF was used to investigate for the first time the phosphoinositide metabolism in a lower avertebrate system. We found that after binding of the cell-binding fragment to the aggregation receptor a strong and rapid stimulation of the phosphate incorporation into… CONTINUE READING

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