Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration.

@article{Krinninger2011RoleOT,
  title={Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration.},
  author={Patricia Krinninger and Cornelia Brunner and Pedro Antonio Ruiz and Elisabeth Schneider and Nikolaus Marx and Anna Foryst-Ludwig and Ulrich Kintscher and Dirk Haller and Helmut Laumen and Hans Hauner},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 2},
  pages={E304-11}
}
Infiltration of immune cells into adipose tissue plays a central role in the pathophysiology of obesity-associated low-grade inflammation. The aim of this study was to analyze the role of adipocyte NF-κB signaling in the regulation of the chemokine/adipokine interferon-γ-induced protein 10 kDa (IP-10) and adipocyte-mediated T cell migration. Therefore, the regulation of IP-10 was investigated in adipose tissue of male C57BL/6J mice, primary human and 3T3-L1 preadipocytes/adipocytes. To… CONTINUE READING