Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.

Abstract

Drug induced long QT syndrome (diLQTS) results primarily from block of the cardiac potassium channel HERG (human-ether-a-go-go related gene). In some cases long QT syndrome can result in the lethal arrhythmia torsade de pointes, an arrhythmia characterized by a rapid heart rate and severely compromised cardiac output. Many patients requiring medication… (More)
DOI: 10.4161/chan.22669

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