Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis.

@article{Gillaspy1995RoleOT,
  title={Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis.},
  author={Allison F. Gillaspy and S G Hickmon and Robert A. Skinner and James R. Thomas and Carl L Nelson and Mark S. Smeltzer},
  journal={Infection and immunity},
  year={1995},
  volume={63 9},
  pages={3373-80}
}
To examine the role of the accessory gene regulator (agr) in staphylococcal osteomyelitis, we compared a Staphylococcus aureus osteomyelitis isolate (UAMS-1) with a derivative of the same strain (UAMS-4) carrying an inactivated agr locus. Virulence was assessed with a rabbit model of acute, exogenous osteomyelitis. Bacteria were delivered by microinjection into the midradial region of the forelimb. After 4 weeks, UAMS-1 was identified in the bone of 12 of 13 rabbits infected with > or = 2 x 10… CONTINUE READING