Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague.

@article{Sebbane2006RoleOT,
  title={Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague.},
  author={Florent Sebbane and Clayton O. Jarrett and Donald Gardner and Daniel R Long and B Joseph Hinnebusch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 14},
  pages={5526-30}
}
Yersinia pestis is transmitted by fleas and causes bubonic plague, characterized by severe local lymphadenitis that progresses rapidly to systemic infection and life-threatening septicemia. Here, we show that although flea-borne transmission usually leads to bubonic plague in mice, it can also lead to primary septicemic plague. However, intradermal injection of Y. pestis, commonly used to mimic transmission by fleabite, leads only to bubonic plague. A Y. pestis strain lacking the plasmid… CONTINUE READING
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Population Biology of Infectious Diseases (Springer, New York)

  • R. M. Anderson, R. M. May
  • 1982

Plague (W.H.O., Geneva)

  • R. Pollitzer
  • 1954

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