Role of the Wnt-β-catenin signaling pathway in melanoma-mediated dendritic cell tolerization

Abstract

Recent studies have shown that tumor immune evasion mechanisms significantly contribute to immunotherapy failure. Emerging data is indicating that tumor-associated dendritic cells (DCs) undergo phenotypic tolerization and promote the differentiation and activation of regulatory T cell (Treg) populations to generate local immune subversion. The critical role… (More)

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Cite this paper

@inproceedings{Holtzhausen2013RoleOT, title={Role of the Wnt-β-catenin signaling pathway in melanoma-mediated dendritic cell tolerization}, author={Alisha Holtzhausen and Kathy Evans and Brent A. Hanks}, year={2013} }