Role of the Vibrio cholerae Matrix Protein Bap1 in Cross-Resistance to Antimicrobial Peptides

@inproceedings{Duperthuy2013RoleOT,
  title={Role of the Vibrio cholerae Matrix Protein Bap1 in Cross-Resistance to Antimicrobial Peptides},
  author={Marylise Duperthuy and Annika E. Sj{\"o}str{\"o}m and Dharmesh Sabharwal and Fatemeh Damghani and Bernt Eric Uhlin and Sun Nyunt Wai},
  booktitle={PLoS pathogens},
  year={2013}
}
Outer membrane vesicles (OMVs) that are released from Gram-negative pathogenic bacteria can serve as vehicles for the translocation of effectors involved in infectious processes. In this study we have investigated the role of OMVs of the Vibrio cholerae O1 El Tor A1552 strain in resistance to antimicrobial peptides (AMPs). To assess this potential role, we grew V. cholerae with sub-lethal concentrations of Polymyxin B (PmB) or the AMP LL-37 and analyzed the OMVs produced and their effects on… CONTINUE READING
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