Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence

@article{Santos2007RoleOT,
  title={Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence},
  author={Camila de Cassia Dos Santos and Graham H. Coombs and Ana Paula Cabral de Araujo Lima and Jeremy C Mottram},
  journal={Molecular Microbiology},
  year={2007},
  volume={66},
  pages={991 - 1002}
}
ICP is a chagasin-family natural tight binding inhibitor of Clan CA, family C1 cysteine peptidases (CPs). We investigated the role of ICP in Trypanosoma brucei by generating bloodstream form ICP-deficient mutants (Deltaicp). A threefold increase in CP activity was detected in lysates of Deltaicp, which was restored to the levels in wild type parasites by re-expression of the gene in the null mutant. Deltaicp displayed slower growth in culture and increased resistance to a trypanocidal synthetic… CONTINUE READING

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