Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

@article{Goldsworthy2008RoleOT,
  title={Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance},
  author={Michelle E. Goldsworthy and Alison J. Hugill and Helen C Freeman and Emma Horner and Kenju Shimomura and Debora Bogani and Guido Pieles and Vesna Mijat and Ruth M Arkell and Shoumo Bhattacharya and Frances M. Ashcroft and Roger D Cox},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2234 - 2244}
}
OBJECTIVES To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS Haploinsufficiency of the insulin receptor and associated mild insulin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify novel mutations resulting in impaired glucose tolerance and diabetes. The new impaired glucose tolerance 4 (IGT4) model was selected using an intraperitoneal glucose… CONTINUE READING