Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells.

@article{TruongBolduc2015RoleOT,
  title={Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells.},
  author={Que Chi Truong-Bolduc and Gilles R Bolduc and Heidi Medeiros and Jatin M Vyas and Yanqun Wang and David C. Hooper},
  journal={Infection and immunity},
  year={2015},
  volume={83 11},
  pages={4362-72}
}
We previously identified the protein Tet38 as a chromosomally encoded efflux pump of Staphylococcus aureus that confers resistance to tetracycline and certain unsaturated fatty acids. Tet38 also contributes to mouse skin colonization. In this study, we discovered a novel regulator of tet38, named tetracycline regulator 21 (TetR21), that bound specifically to the tet38 promoter and repressed pump expression. A ΔtetR21 mutant showed a 5-fold increase in tet38 transcripts and an 8-fold increase in… CONTINUE READING
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