Role of the TSG101 gene in Epstein-Barr virus late gene transcription.

@article{Chua2007RoleOT,
  title={Role of the TSG101 gene in Epstein-Barr virus late gene transcription.},
  author={Huey-Huey Chua and Heng-Huan Lee and Shih-Shin Chang and Chih-Chung Lu and Te-Huei Yeh and Tsuey-Ying Hsu and Tzu-Hao Cheng and J. Wood-Hi Cheng and Mei-Ru Chen and Ching-Hwa Tsai},
  journal={Journal of virology},
  year={2007},
  volume={81 5},
  pages={
          2459-71
        }
}
Rta, an Epstein-Barr virus (EBV)-encoded immediate-early protein, governs the reactivation of the viral lytic program by transactivating a cascade of lytic gene expression. Cellular transcription factors such as Sp1, ATF2, E2F, and Akt have been demonstrated to mediate Rta transactivation of lytic genes. We report herein that Rta associates with another potent transcription factor, tumor susceptibility gene 101 (TSG101), to promote the activation of EBV late genes. Results from an EBV cDNA… CONTINUE READING

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