Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.

@article{Pereira2014RoleOT,
  title={Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.},
  author={Vanessa Pereira and J{\'e}r{\^o}me Busserolles and Marine Christin and Ma{\"i}ly Devilliers and Laura Poupon and Wassim Legha and Abdelkrim Alloui and Youssef Aissouni and Emmanuel Bourinet and Florian Lesage and Alain Eschalier and Michel Lazdunski and Jacques No{\"e}l},
  journal={Pain},
  year={2014},
  volume={155 12},
  pages={2534-44}
}
Two-pore domain background K(+) channels (K2p or KCNK) produce hyperpolarizing currents that control cell membrane polarity and neuronal excitability throughout the nervous system. The TREK2 channel as well as the related TREK1 and TRAAK channels are mechanical-, thermal- and lipid-gated channels that share many regulatory properties. TREK2 is one of the major background channels expressed in rodent nociceptive neurons of the dorsal root ganglia that innervate the skin and deep body tissues… CONTINUE READING
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