Role of the Sensory Neuron Cytoskeleton in Second Messenger Signaling for Inflammatory Pain

@article{Dina2003RoleOT,
  title={Role of the Sensory Neuron Cytoskeleton in Second Messenger Signaling for Inflammatory Pain},
  author={Olayinka A Dina and Gordon C McCarter and Catherine de Coupade and Jon D Levine},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={613-624}
}
Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively. Disruptors of the cytoskeleton (microfilaments, microtubules, and intermediate filaments) markedly attenuated the hyperalgesia in rat paws caused by injection of epinephrine or its downstream mediators. In contrast, the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 91 references

Protein-protein interactions at mechanotransduction in the nematode Caenorhabditis elegans

  • G. Milligan, J. H. White
  • 2001
Highly Influential
8 Excerpts

induced painful peripheral neuropathy in the rat

  • K. O. Aley, R. O. Messing, D. Mochly-Rosen, J. D. Levine
  • 2000
Highly Influential
14 Excerpts

Mechanical hyper-responsiveness during vincristine-induced painful peripheral

  • G. C. McCarter, D. B. Reichling, J. D. Levine
  • 1999
Highly Influential
3 Excerpts

G-protein coupled receptors

  • O. El Far, H. Betz
  • 2002
1 Excerpt

MEK mediates v-Src-induced cytoskeleton of large diameter sensory neurons and myelinated

  • G. Pawlak, D. M. Helfman
  • 2002
2 Excerpts

Mechanotransduction through toskeleton

  • M. J. Kelly, E. J. Wagner
  • Cell . Signal . Am . J . Physiol . Cell Physiol .
  • 2002

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