Role of the Sensory Neuron Cytoskeleton in Second Messenger Signaling for Inflammatory Pain

  title={Role of the Sensory Neuron Cytoskeleton in Second Messenger Signaling for Inflammatory Pain},
  author={Olayinka A Dina and Gordon C McCarter and Catherine de Coupade and Jon D Levine},
Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively. Disruptors of the cytoskeleton (microfilaments, microtubules, and intermediate filaments) markedly attenuated the hyperalgesia in rat paws caused by injection of epinephrine or its downstream mediators. In contrast, the… CONTINUE READING


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