Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia.

@article{MartnezLostao2005RoleOT,
  title={Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia.},
  author={Luis Mart{\'i}nez-Lostao and J. J. Quijano Briones and Ignasi Forn{\'e} and Monica Martinez-Gallo and Beatriz Socarr{\'a}s Ferrer and Jos{\'e}M. Sierra and Jos{\'e} Lu{\'i}s Rodr{\'i}guez-S{\'a}nchez and Candido Juarez},
  journal={Leukemia & lymphoma},
  year={2005},
  volume={46 3},
  pages={
          435-42
        }
}
Signal transducers and activators of transcription (STAT) proteins comprise a family of transcription factors that have been implicated in tumoral transformation, especially in hematological malignancies. Because of this, the JAK/STAT pathway is attractive as a therapeutic target in these tumors. In the present study, we analyzed the ability of fludarabine and two JAK kinase inhibitors, AG490 and WHI-P131, to block STAT1 activation and induce apoptosis on B-cell chronic lymphocytic leukemia (B… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Similar Papers

Loading similar papers…