Role of the SNK-SPAR pathway in the development of Alzheimer's disease.

@article{Gong2010RoleOT,
  title={Role of the SNK-SPAR pathway in the development of Alzheimer's disease.},
  author={Xiaoyang Gong and Xiaoguang Lu and Li-bin Zhan and Hua Sui and Xin Qi and Zhenghong Ji and Xinping Niu and Li Liu},
  journal={IUBMB life},
  year={2010},
  volume={62 3},
  pages={214-21}
}
Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underlying dendritic spine damage that is induced by Abeta toxicity in AD patients remain largely unknown. It has been suggested previously that the SNK-SPAR signaling pathway is… CONTINUE READING