Role of the Nlrp3 Inflammasome in Microbial Infection

  title={Role of the Nlrp3 Inflammasome in Microbial Infection},
  author={Paras K Anand and R K Subbarao Malireddi and Thirumala-Devi Kanneganti},
  booktitle={Front. Microbio.},
The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 25 extracted citations

The roles of odontoblasts in dental pulp innate immunity

The Japanese dental science review • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 63 references

Staphylococcus aureus

J A.
View 4 Excerpts
Highly Influenced

Cryopyrin activates

S. Mariathasan, D. S. Weiss, +7 authors V. M. Dixit
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…