Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.

@article{Okafuji2009RoleOT,
  title={Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.},
  author={Ikuo Okafuji and Ryuta Nishikomori and Nobuo Kanazawa and Naotomo Kambe and Akihiro Fujisawa and Shin Yamazaki and Megumu K Saito and Takakazu Yoshioka and Tomoki Kawai and Hidemasa Sakai and Hideaki Tanizaki and Toshio Heike and Yoshiki Miyachi and Tatsutoshi Nakahata},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 1},
  pages={242-50}
}
OBJECTIVE Blau syndrome and its sporadic counterpart, early-onset sarcoidosis (EOS), share a phenotype featuring the symptom triad of skin rash, arthritis, and uveitis. This systemic inflammatory granulomatosis is associated with mutations in the NOD2 gene. The aim of this study was to describe the clinical manifestations of Blau syndrome/EOS in Japanese… CONTINUE READING