Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.

@article{Narita2001RoleOT,
  title={Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.},
  author={Minoru Narita and Kazumi Yoshizawa and Mutsuko Nomura and Kazue Aoki and Takaharu Suzuki},
  journal={European journal of pharmacology},
  year={2001},
  volume={423 1},
  pages={41-6}
}
Ketamine, which is a non-competitive NMDA receptor antagonist, has been used as a dissociative anesthetic agent. However, chronic use of ketamine produces psychotomimetic effects, such as nightmares, hallucination and delusion. Therefore, the present study was designed to ascertain the role of the NMDA receptor and sigma receptor in the discriminative stimulus effect induced by ketamine. Fischer 344 rats were trained to discriminate between ketamine (5 mg/kg, i.p.) and saline under a fixed… CONTINUE READING