Role of the M1 receptor in regulating circadian rhythms.

  title={Role of the M1 receptor in regulating circadian rhythms.},
  author={Martha L U Gillette and Gordon F. Buchanan and Liana Artinian and Susan E. Hamilton and Neil M. Nathanson and C Liu},
  journal={Life sciences},
  volume={68 22-23},
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the… CONTINUE READING