Role of the LAT adaptor in T-cell development and Th2 differentiation.

@article{Malissen2005RoleOT,
  title={Role of the LAT adaptor in T-cell development and Th2 differentiation.},
  author={Bernard Malissen and Enrique Fern{\'a}ndez Aguado and Marie Malissen},
  journal={Advances in immunology},
  year={2005},
  volume={87},
  pages={1-25}
}
LAT (linker for activation of T cells) is an integral membrane adaptor protein that constitutes in T cells a major substrate of the ZAP-70 protein tyrosine kinase. LAT coordinates the assembly of a multiprotein signaling complex through phosphotyrosine-based motifs present within its intracytoplasmic segment. The resulting "LAT signalosome" links the TCR to the main intracellular signalling pathways that regulate T-cell development and T-cell function. Early studies using transformed T-cell… CONTINUE READING