Role of the Kidney in Erythropoiesis

@article{Jacobson1957RoleOT,
  title={Role of the Kidney in Erythropoiesis},
  author={L. Jacobson and E. Goldwasser and W. Fried and L. Plzak},
  journal={Nature},
  year={1957},
  volume={179},
  pages={633-634}
}
RECENT observations in our laboratory indicate that the dynamic equilibrium of the erythron is controlled by the relationship of oxygen supply in the tissue to the demand for oxygen rather than by either alone. Conditions that reduce the demand for oxygen while the supply remains normal (acute starvation and the condition following hypophysectomy) and ones that increase the supply of oxygen while the demand remains normal (transfusion-induced polycythæmia and hyperoxia) all produce a profound… Expand
Regulation of Erythropoiesis and Possible Implications of the Cell Membrane
The regulation of erythropoiesis and, finally, of the erythrocyte count and of the amount of circulating hemoglobin on which the volume of oxygen transported by the blood from the lungs toward theExpand
Role of the kidneys in erythropoietin production
TLDR
Investigators have failed to discover an increase in erythropoietic activity of the blood following isolated anoxia and perfusion of the kidneys. Expand
The molecular mechanism of erythropoietin action.
Erythropoietin (EPO) is the glycoprotein hormone which controls the production of erythrocytes in mammals. Erythrocytes contain hemoglobin which delivers oxygen from the lungs to other tissuesExpand
Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?
The glycoprotein hormone erythropoietin (Epo) is an obligatory growth and differentiation factor for the erythrocytic progenitors. The plasma level of Epo in the human is about 5 to 25 mU/m1 underExpand
Role of Erythrogenin from Liver and Spleen in Erythropoietin Production in the Anephric Rat
TLDR
Evidence is presented indicating that under both normal and hypoxic conditions the production of circulating Ep involves the interaction of a renal erythropoietic factor (also termed erythrogenin) with a serum protein component. Expand
Role of erythropoietin in adaptation to hypoxia
TLDR
It is concluded that the ‘oxygen sensor’ that controls hypoxia-induced EPO synthesis is located in the kidney itself and the local venous oxygen tension which reflects the ratio of oxygen supply to oxygen consumption is measured and transformed into a signal that regulates the formation of EPO. Expand
Biogenesis of Erythropoietin
The concept that the kidney serves as the principal site of production or activation of erythropoietin (erythropoiesis stimulating factor, ESF) has gained credence from several lines of evidence. TheExpand
Studies on extrarenal erythropoietin.
TLDR
It is indicated that extrarenal erythropoietin is probably identical to that of renal origin, and its production is regulated by the intensity of hypoxia. Expand
Regulating mechanisms involved in the expression of the erythropoietin gene.
TLDR
The hypothesis is that it is the tissue oxygen tension, as determined by the supply and demand of oxygen, that regulates red blood cell production, rather than arterial oxygen pressure per se, which provides the mechanisms to respond to anemia or hypoxia. Expand
ERYTHROPOIETIC FACTOR IN THE CONTROL OF RED CELL PRODUCTION *
  • A. Erslev
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1959
TLDR
Clinical and experimental observations have shown that, although the nutritional and hormonal environment conditions the rate of red cell production and hemoglobin synthesis, an anoxic stimulus is necessary in order to balancered cell production with the body's need for oxygen. Expand
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References

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Erythropoiesis. II. Assay of Erythropoietin in Hypophysectomized Rats.∗
TLDR
Using incorporation of Fe59 into newly-formed red cells as index of red cell production, it has been shown that erythropoiesis is gradually reduced, reaching a minimum in rats at 8 to 13 days after hypophysectomy. Expand
Erythropoietic Stimulating Effects of Plasma Extracts from Anemic Human Subjects
Summary Boiled filtrates of acidified plasma obtained from 7 patients with Cooley's anemia and one of 2 patients with sickle cell anemia stimulated erythropoiesis in intact rats. A similarly preparedExpand
Plasma Factor(s) influencing Red Cell Production
THERE is an accumulating body of evidence of the existence of a humoral substance(s) in the plasma of animals with induced anæmia which stimulates erythropoiesis in recipients1.