Role of the Kidney in Erythropoiesis

@article{Jacobson1957RoleOT,
  title={Role of the Kidney in Erythropoiesis},
  author={Leon O. Jacobson and Eugene Goldwasser and Walter Fried and Louis F. Plzak},
  journal={Nature},
  year={1957},
  volume={179},
  pages={633-634}
}
RECENT observations in our laboratory indicate that the dynamic equilibrium of the erythron is controlled by the relationship of oxygen supply in the tissue to the demand for oxygen rather than by either alone. Conditions that reduce the demand for oxygen while the supply remains normal (acute starvation and the condition following hypophysectomy) and ones that increase the supply of oxygen while the demand remains normal (transfusion-induced polycythæmia and hyperoxia) all produce a profound… 

Regulation of Erythropoiesis and Possible Implications of the Cell Membrane

The regulation of erythropoiesis and, finally, of the erythrocyte count and of the amount of circulating hemoglobin on which the volume of oxygen transported by the blood from the lungs toward the

Role of the kidneys in erythropoietin production

Investigators have failed to discover an increase in erythropoietic activity of the blood following isolated anoxia and perfusion of the kidneys.

EFFECT OF ANEMIC HYPOXIA ON ERYTHROPOIESIS OF NORMAL AND UREMIC DOGS WITH OR WITHOUT KIDNEYS.

  • J. NaetsA. Heuse
  • Medicine, Biology
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1964
From these experiments, it could be assumed that the kidney of the dog elaborates an erythropoietic factor indispensable for normal daily production of red cells, however of uremic of cells.

The molecular mechanism of erythropoietin action.

Erythropoietin (EPO) is the glycoprotein hormone which controls the production of erythrocytes in mammals. Erythrocytes contain hemoglobin which delivers oxygen from the lungs to other tissues

Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?

The glycoprotein hormone erythropoietin (Epo) is an obligatory growth and differentiation factor for the erythrocytic progenitors and may increase to 1000 mU/ml or more after the induction of anemia or hypoxic hypoxia.

Role of Erythrogenin from Liver and Spleen in Erythropoietin Production in the Anephric Rat

Evidence is presented indicating that under both normal and hypoxic conditions the production of circulating Ep involves the interaction of a renal erythropoietic factor (also termed erythrogenin) with a serum protein component.

Role of erythropoietin in adaptation to hypoxia

It is concluded that the ‘oxygen sensor’ that controls hypoxia-induced EPO synthesis is located in the kidney itself and the local venous oxygen tension which reflects the ratio of oxygen supply to oxygen consumption is measured and transformed into a signal that regulates the formation of EPO.

Biogenesis of Erythropoietin

It is shown that nephrectomy inhibited the erythropoietic response of rats to hemorrhage, lowered barometric pressures and cobalt administration, and Nephrectomized animals showed a markedly diminished capacity to produce ESF when exposed to these stimuli.

Studies on extrarenal erythropoietin.

It is indicated that extrarenal erythropoietin is probably identical to that of renal origin, and its production is regulated by the intensity of hypoxia.

Regulating mechanisms involved in the expression of the erythropoietin gene.

The hypothesis is that it is the tissue oxygen tension, as determined by the supply and demand of oxygen, that regulates red blood cell production, rather than arterial oxygen pressure per se, which provides the mechanisms to respond to anemia or hypoxia.
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References

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Erythropoiesis. II. Assay of Erythropoietin in Hypophysectomized Rats.∗

Using incorporation of Fe59 into newly-formed red cells as index of red cell production, it has been shown that erythropoiesis is gradually reduced, reaching a minimum in rats at 8 to 13 days after hypophysectomy.

Erythropoietic Stimulating Effects of Plasma Extracts from Anemic Human Subjects

Summary Boiled filtrates of acidified plasma obtained from 7 patients with Cooley's anemia and one of 2 patients with sickle cell anemia stimulated erythropoiesis in intact rats. A similarly prepared

Plasma Factor(s) influencing Red Cell Production

THERE is an accumulating body of evidence of the existence of a humoral substance(s) in the plasma of animals with induced anæmia which stimulates erythropoiesis in recipients1.