Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.

@article{Tong2013RoleOT,
  title={Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.},
  author={Jin Tong and Xiang-Dong Zhou and Victor P. Kolosov and Juliy M. Perelman},
  journal={International immunopharmacology},
  year={2013},
  volume={17 3},
  pages={821-7}
}
The aim of this study was to investigate the regulatory role of the c-JUN N-terminal kinase (JNK) pathway on interleukin (IL)-8 and tumor necrosis factor (TNF)-α expression in alveolar macrophages (AMs) of injured lung. Lung injury was induced in the New Zealand white rabbit by applying continuous mechanical ventilation with or without inhibitor of JNK… CONTINUE READING