Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells.

@article{Miho2005RoleOT,
  title={Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells.},
  author={Narimasa Miho and Takafumi Ishida and Noriko Kuwaba and M. Ishida and Keiko Shimote-Abe and Kumiko Tabuchi and Tetsuya Oshima and Masao Yoshizumi and Kazuaki Chayama},
  journal={Cardiovascular research},
  year={2005},
  volume={68 2},
  pages={289-98}
}
OBJECTIVE Thrombin induces leukocyte adherence to endothelial cells via increased expression of intercellular adhesion molecule-1 (ICAM-1). Although ICAM-1 expression is regulated by NF-kappaB, recent studies have suggested that additional signaling mechanisms may also be involved. The goal of this study was to determine whether mitogen-activated protein (MAP) kinases, including extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAP kinase (p38), mediate… CONTINUE READING