Role of the Intestinal Immune System in the Pathogenesis of Autoimmune Diabetes in the BB Rat Model of Type 1 Diabetes Mellitus

Abstract

The intestine is the largest lymphoid organ in the body, challenged constantly by an enormous quantity and diversity of antigens. Distinct from peripheral lymphocytes intestinal lymphocytes have evolved unique mechanisms of tolerance and appear to govern mucosal processes such as "chronic physiologic inflammation" and oral tolerance. Failure of mucosal… (More)

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