Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population.

  title={Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population.},
  author={Orlando A Torres and Jos{\'e} Eduardo Calzada and Yasmina Bera{\'u}n and Carlos A. Morillo and Antonio Poyato Gonz{\'a}lez and Clara I. Gonzalez and Javier Mart{\'i}n},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  volume={10 5},
Genetic susceptibility to Trypanosoma cruzi infection and the development of cardiomyopathy is complex, heterogeneous, and likely involves several genes. Previous studies have implicated cytokine and chemokine genes in susceptibility to Chagas disease. Here we investigated the association between the interferon-gamma gene (IFNG) +874T/A polymorphism and Chagas disease, focusing on susceptibility and severity. This study included 236 chagasic patients (asymptomatic, n=116; cardiomyopathic, n=120… CONTINUE READING

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