Role of the Gut Endoderm in Relaying Left-Right Patterning in Mice

@inproceedings{Viotti2012RoleOT,
  title={Role of the Gut Endoderm in Relaying Left-Right Patterning in Mice},
  author={Manuel Viotti and Lei Niu and Song-Hai Shi and Anna-Katerina Hadjantonakis},
  booktitle={PLoS biology},
  year={2012}
}
Establishment of left-right (LR) asymmetry occurs after gastrulation commences and utilizes a conserved cascade of events. In the mouse, LR symmetry is broken at a midline structure, the node, and involves signal relay to the lateral plate, where it results in asymmetric organ morphogenesis. How information transmits from the node to the distantly situated lateral plate remains unclear. Noting that embryos lacking Sox17 exhibit defects in both gut endoderm formation and LR patterning, we… CONTINUE READING
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