Role of the GALT in scrapie agent neuroinvasion from the intestine.

@article{Glaysher2007RoleOT,
  title={Role of the GALT in scrapie agent neuroinvasion from the intestine.},
  author={Bridget R. Glaysher and Neil A Mabbott},
  journal={Journal of immunology},
  year={2007},
  volume={178 6},
  pages={3757-66}
}
Following oral exposure, some transmissible spongiform encephalopathy (TSE) agents accumulate first upon follicular dendritic cells (FDCs) in the GALT. Studies in mice have shown that this accumulation is obligatory for the efficient delivery of the TSE agent to the brain. However, which GALTs are crucial for disease pathogenesis is uncertain. Mice deficient in specific GALT components were used here to determine their separate involvement in scrapie agent neuroinvasion from the intestine. In… CONTINUE READING

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