Role of the ERK-mediated signaling pathway in mesenchyme formation and differentiation in the sea urchin embryo.

@article{FernandezSerra2004RoleOT,
  title={Role of the ERK-mediated signaling pathway in mesenchyme formation and differentiation in the sea urchin embryo.},
  author={Montserrat Fernandez-Serra and Claudia Consales and Alessandra Livigni and Maria Ina Arnone},
  journal={Developmental biology},
  year={2004},
  volume={268 2},
  pages={384-402}
}
Mesoderm and mesodermal structures in the sea urchin embryo are entirely generated by two embryologically distinct populations of mesenchyme cells: the primary (PMC) and the secondary (SMC) mesenchyme cells. We have identified the extracellular signal-regulated kinase (ERK) as a key component of the regulatory machinery that controls the formation of both these cell types. ERK is activated in a spatial-temporal manner, which coincides with the epithelial-mesenchyme transition (EMT) of the… CONTINUE READING

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