Role of the EHD2 Unstructured Loop in Dimerization, Protein Binding and Subcellular Localization

@inproceedings{Bahl2015RoleOT,
  title={Role of the EHD2 Unstructured Loop in Dimerization, Protein Binding and Subcellular Localization},
  author={Kriti Bahl and Naava Naslavsky and Steve Caplan},
  booktitle={PloS one},
  year={2015}
}
The C-terminal Eps 15 Homology Domain proteins (EHD1-4) play important roles in regulating endocytic trafficking. EHD2 is the only family member whose crystal structure has been solved, and it contains an unstructured loop consisting of two proline-phenylalanine (PF) motifs: KPFRKLNPF. In contrast, despite EHD2 having nearly 70% amino acid identity with its… CONTINUE READING