Role of the CD8+ dendritic cell subset in transmission of prions.

  title={Role of the CD8+ dendritic cell subset in transmission of prions.},
  author={Shneh Sethi and Kristen M. Kerksiek and Thomas Brocker and Hans A. Kretzschmar},
  journal={Journal of virology},
  volume={81 9},
Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11c(hi) DC has been described, and the remaining CD8+ DC demonstrate a reduced capacity for the uptake of apoptotic cells. After intraperitoneal prion infection, significantly longer incubation times were observed in CD11c-N17Rac1… CONTINUE READING

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