Role of the C5b-9 complement complex in cell cycle and apoptosis.

  title={Role of the C5b-9 complement complex in cell cycle and apoptosis.},
  author={Horea G Rus and Florin Niculescu and Moon L. Shin},
  journal={Immunological reviews},
Assembly of C5b-9 on cell membranes results in transmembrane channels and causes cell death. When the number of C5b-9 molecules is limited, nucleated cells are able to escape cell death by endocytosis and by shedding of membranes bearing C5b-9. Sublytic CSb-9 induces proto-oncogenes, activates the cell cycle, and enhances cell survival. In addition, C5b-9 reverses the differentiated phenotype of postmitotic cells, such as oligodendrocytes and skeletal muscle cells. The signal transduction… CONTINUE READING


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