Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes

@inproceedings{Emerson2010RoleOT,
  title={Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes},
  author={Vanessa Emerson and Claudia M Haller and Tanya Pfeiffer and Oliver T. Fackler and Valerie Bosch},
  booktitle={Retrovirology},
  year={2010}
}
Mutant HIV (HIV-Env-Tr712) lacking the cytoplasmic tail of the viral glycoprotein (Env-CT) exhibits a cell-type specific replication phenotype such that replicative spread occurs in some T-cell lines (referred to as permissive cells) but fails to do so in most T-cell lines or in PBMCs (referred to as non-permissive cells). We aim to gain insight on the underlying requirement for the Env-CT for viral spread in non-permissive cells. We established that in comparison to HIV-Wt, both cell-free and… CONTINUE READING