Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.

@article{Quinlan2006RoleOT,
  title={Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.},
  author={Kate G. R. Quinlan and Alexis Verger and Alister Kwok and Stella Yu-Chien Lee and Jos{\'e} Perdomo and Marco Nardini and Martino Bolognesi and Merlin Crossley},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 21},
  pages={8202-13}
}
C-terminal binding proteins (CtBPs) are multifunctional proteins that can mediate gene repression. CtBPs contain a cleft that binds Pro-X-Asp-Leu-Ser (PXDLS) motifs. PXDLS motifs occur in numerous transcription factors and in effectors of gene repression, such as certain histone deacetylases. CtBPs have been depicted as bridging proteins that self-associate and link PXDLS-containing transcription factors to PXDLS-containing chromatin-modifying enzymes. CtBPs also recruit effectors that do not… CONTINUE READING

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