Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice

@article{Hayashi2004RoleOT,
  title={Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice},
  author={Masaaki Hayashi and Jiing-Dwan Lee},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={82},
  pages={800-808}
}
Mitogen-activated protein (MAP) kinase cascades play a central role in mediating extracellular stimuli-induced intracellular signaling during cell activation. The fourth and least studied mammalian MAP kinase pathway, big MAP kinase 1 (BMK1), also known as extracellular signal regulated kinase 5 (ERK5), is activated in response to growth factors and stress. Activation of this signaling pathway has been implicated not only in physiological functions such as cell survival, proliferation and… Expand
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