Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

@inproceedings{Turnbull2016RoleOT,
  title={Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity},
  author={Matthew Luke Turnbull and Helen M. Wise and Marlynne Quigg Nicol and Nikki Smith and Rebecca L. Dunfee and Philippa M Beard and Brett W. Jagger and Yvonne Ligertwood and Gareth Rhys Hardisty and Haixia Xiao and Donald J Benton and Alice Miranda Coburn and Joao A. Paulo and Steven P Gygi and John W. McCauley and Jeffery K. Taubenberger and S Lycett and Michael P Weekes and Bernadette M. Dutia and Paul Digard},
  booktitle={Journal of virology},
  year={2016}
}
UNLABELLED Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele is found in avian and mammalian viruses, but the B allele is viewed as being almost exclusively found in avian viruses. This might reflect the fact that one or both of its encoded proteins (NS1 and NEP) are maladapted for replication in mammalian hosts. To test this, a number of clade A and B avian virus-derived NS segments were introduced into human H1N1 and H3N2 viruses. In no case was the… CONTINUE READING
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