Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus.

@article{Kerkvliet1990RoleOT,
  title={Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus.},
  author={Nancy I Kerkvliet and Linda Baecher-Steppan and Benjamin B Smith and J A Youngberg and Marilyn C. Henderson and Donald R. Buhler},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1990},
  volume={14 3},
  pages={532-41}
}
Previous studies have shown that the generation of cytotoxic T lymphocytes (CTL) following allogeneic tumor challenge is suppressed in Ah-responsive C57Bl/6 mice treated with a single oral dose of the toxic, Ah receptor-binding 3,4,5,3',4',5'-hexachlorobiphenyl (HxCB). The present studies have examined the specific role of the Ah receptor in this immunotoxic response by utilizing HxCB isomers of known, varied affinity for the Ah receptor as well as by comparing effects of high-affinity Ah… CONTINUE READING

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