Role of the Adipocyte in Development of Type 2 Diabetes

  title={Role of the Adipocyte in Development of Type 2 Diabetes},
  author={Colleen M Croniger},
13 Citations

Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial

A ketogenic diet may provide an easy-to-apply and cost-effective treatment option potentially alleviating sepsis-evoked harm and the effect on the immune system is analysed.

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

The decreased L-carnitine content in the heart preserves its peroxisomal and mitochondrial function after ischemia and improves cardiac recovery during reperfusion and provides a foundation for novel cardioprotective mechanisms.

The need for co-ordinated studies for obesity-related problems like diabetes mellitus in Libyan population

Excess lipolysis causing increased concentrations of non-esterified fatty acids and triglycerides in blood and skeletal muscle and Muscle glucose uptake is suppressed indicates obesity is one of the major risk factors of type 2 diabetes.

Beyond Dietary Fatty Acids as Energy Source: A Point of View for the Prevention and Management of Type 2 Diabetes

The review of studies in insulin-secreting cell lines, islet cells, animal models, and human beings that have informed the current understanding of the mechanistic links among dietary fatty acids, beta-cell function, and insulin sensitivity are reviewed.

The Sick Adipocyte Theory: The Forces of Clustering at Glance

Being obese is not only a matter of Body Mass Index (BMI) and adiposity, its influence stretches out to include type 2 Diabetes Mellitus (T2DM), Psychological disorders like depression, anxiety disorders, and other eating disorders, Osteoarticular problems, Metabolic Syndrome, Cardiovascular diseases, and even Immunity-related issues.

Obesity and Systemic Inflammation: Insights into Epigenetic Mechanisms

Obesity is defined by excess accumulation of white adipose mass, resulting from both an increase in adipocyte cell size (hypertrophy) and the development of new mature cells from undifferentiated precursors (hyperplasia) (Heine et al., 2000; Naaz et al, 2004).

Assessment of Abdominal Adiposity and Organ Fat with Magnetic Resonance Imaging

The described methods are useful in preventive medicine for early detection of health risks, in studies for identifying changes in subcutaneous and visceral adipose tissue volumes due to intervention, such as bariatric surgery and diet, and in comparing trends between gender and ethnicity groups.

The Role of Adipose Tissue in Diabetic Kidney Disease

The role of altered renal lipid metabolism has not yet been extensively studied in obesity-related kidney disease, including diabetic nephropathy, but previous reports have revealed that abnormalities in lipid and glucose metabolism in the kidney are also important in the development of organ injury.

Interactions Between Total Plasma Homocysteine, Oxidized LDL Levels, Thiolactonase Activities and Dietary Habits in Tunisian Diabetic Patients

Among the main determinants of tHcy levels in non-diabetic subjects are age, sex, renal function, several diseases, drugs, coffee and chronic alcohol consumption, smoking and physical inactivity.

Oxidative Stress in Type II Diabetes Mellitus and the Role of the Endogenous Antioxidant Glutathione

Oxidative stress appears to be involved in aging and a great many diseases, including diabetes mellitus, and is inferred from the accumulation of oxidation products, such as plasma O2●radicals or high levels of peroxidation products such as thiobarbituric acid-reactive substances in plasma.



Muscle fiber type specificity in insulin signal transduction.

Increased function and/or expression of key proteins in the insulin-signaling cascade contribute to fiber type-specific differences in insulin action in skeletal muscle.

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.

It is suggested that macrophages alter the inflammatory state of muscle cells in an obese milieu, inhibiting insulin signaling, and in obesity both adipose tissue and skeletal muscle inflammation may contribute to insulin resistance.

Pharmacokinetics of L-Carnitine

The renal clearance of L-carnitine increases after exogenous administration, approaching GFR after high intravenous doses, and many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular re absorption.

Archaeology of NIDDM: Excavation of the “Thrifty” Genotype

It is hypothesized that those Paleo-Indians who relied on big game as a food source developed a “thrifty” genotype that allowed a selective advantage during the periods of fasting that occurred between big game kills and may contribute to NIDDM.

The epidemiology and natural history of NIDDM--lessons from the South Pacific.

Skeletal Muscle Insulin Resistance: Roles of Fatty Acid Metabolism and Exercise

A single session of aerobic exercise increases glucose uptake by muscle during exercise, increases the ability of insulin to promote glucose uptake, and increases glycogen accumulation after exercise, all of which are important to blood glucose control.