Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation.

@article{Pulgar2011RoleOT,
  title={Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation.},
  author={Victor M Pulgar and Henry Yamashiro and J Cameron Rose and Lorna Grindlay Moore},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  year={2011},
  volume={12 3},
  pages={176-83}
}
INTRODUCTION During human pregnancy, circulating concentrations of components of the renin-angiotensin system increase, but pressor refractoriness to angiotensin II (Ang-II) is observed. Given the importance of the Ang-II pressor response in deciding susceptibility to preeclampsia and of the Ang-II system for controlling uterine vasoreactivity, we sought to address the effects of pregnancy on the reactivity of the isolated uterine artery (UA) in mice. MATERIALS AND METHODS Blood pressure was… CONTINUE READING

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