Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

  title={Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives},
  author={Annie Matthys and Guy Haegeman and Kathleen Van Craenenbroeck and Peter Vanhoenacker},
  journal={Molecular Neurobiology},
Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models… 

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Preclinical findings suggest that blockade of this receptor may be beneficial against schizophrenia-like cognitive deficits and the question is whether the beneficial effects may be achieved by activation or blockade of 5-HT7Rs.

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S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior

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  • L. HeislerH. Chu L. Tecott
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
Results indicate that the targeted disruption of the 5-HT1A receptor gene leads to heritable perturbations in the serotonergic regulation of emotional state.