Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

@article{Matthys2011RoleOT,
  title={Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives},
  author={Annie Matthys and Guy Haegeman and Kathleen Van Craenenbroeck and Peter Vanhoenacker},
  journal={Molecular Neurobiology},
  year={2011},
  volume={43},
  pages={228-253}
}
Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models… 

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