• DOI:10.1016/0041-008X(81)90236-2
Corpus ID: 27984348

Role of terminal substituents in the pulmonary toxicity of bleomycins.

@article{Raisfeld1981RoleOT,
  title={Role of terminal substituents in the pulmonary toxicity of bleomycins.},
  author={I. Raisfeld},
  journal={Toxicology and applied pharmacology},
  year={1981},
  volume={57 3},
  pages={
          355-66
        }
}

I. Raisfeld

Published 1981

Chemistry, Medicine

Toxicology and applied pharmacology

Abstract When administered to mice by the intratracheal route, bleomycin analogs produce pulmonary toxicity of varying severity. Analogs differ from each other by chemical groups (terminal substituents) linked to the bithiazole rings. Amines with structures identical to the terminal substituents of bleomycins A2′-a, A2′-b, A2′-c, A5, A6, and B2 were administered to mice endotracheally (10–500 nmol). Discrete end groups produced the same spectrum of pathological changes in the lung as did intact… CONTINUE READING

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