Role of terminal substituents in the pulmonary toxicity of bleomycins.

@article{Raisfeld1981RoleOT,
  title={Role of terminal substituents in the pulmonary toxicity of bleomycins.},
  author={I. Raisfeld},
  journal={Toxicology and applied pharmacology},
  year={1981},
  volume={57 3},
  pages={
          355-66
        }
}
  • I. Raisfeld
  • Published 1981
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • Abstract When administered to mice by the intratracheal route, bleomycin analogs produce pulmonary toxicity of varying severity. Analogs differ from each other by chemical groups (terminal substituents) linked to the bithiazole rings. Amines with structures identical to the terminal substituents of bleomycins A2′-a, A2′-b, A2′-c, A5, A6, and B2 were administered to mice endotracheally (10–500 nmol). Discrete end groups produced the same spectrum of pathological changes in the lung as did intact… CONTINUE READING
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    References

    SHOWING 1-10 OF 28 REFERENCES
    Pulmonary toxicity of bleomycin analogs.
    • I. Raisfeld
    • Medicine
    • Toxicology and applied pharmacology
    • 1980
    • 40
    Synthesis and the lethality of bleomycin in bacteria.
    • 17
    • PDF
    Bleomycin-induced interstitial pneumonia in dogs
    • 113
    • PDF
    The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.
    • 447
    Bleomycin-induced diffuse interstitial pulmonary fibrosis in baboons.
    • 105
    • PDF
    Multiple forms of amine oxidase in perfused rabbit lung.
    • J. Roth, C. N. Gillis
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1975
    • 60