Role of telomeres and telomerase in genomic instability, senescence and cancer

  title={Role of telomeres and telomerase in genomic instability, senescence and cancer},
  author={Yibin Deng and Sandy Chang},
  journal={Laboratory Investigation},
Telomeres are ribonucleoprotein structures that protect the end of linear chromosomes from recognition as DNA double-stranded breaks and activation of a DNA damage response. Telomere-associated proteins also regulate telomerase, the protein responsible for maintaining telomere length. Loss of telomere function results from either alteration in the capping function at telomeres, or from progressive loss of telomeric repeats necessary to maintain proper telomeric structure. Dysfunctional… CONTINUE READING

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