Role of telomere dysfunction in aging and its detection by biomarkers

@article{Figura2009RoleOT,
  title={Role of telomere dysfunction in aging and its detection by biomarkers},
  author={Guido von Figura and Daniel Hartmann and Zhangfa Song and K Lenhard Rudolph},
  journal={Journal of Molecular Medicine},
  year={2009},
  volume={87},
  pages={1165-1171}
}
Aging is a complex process that has been shown to be linked to accumulation of DNA damage. Telomere shortening represents a cell-intrinsic mechanism leading to DNA damage accumulation and activation of DNA damage checkpoints in aging cells. Activation of DNA damage checkpoints in response to telomere dysfunction results in induction of cellular senescence—a permanent cell cycle arrest. Senescence represents a tumor suppressor mechanism protecting cells from evolution of genomic instability and… CONTINUE READING

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