Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections

@article{Weidenmaier2004RoleOT,
  title={Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections},
  author={Christopher Weidenmaier and John F Kokai-Kun and Sascha A. Kristian and Tanya Chanturiya and Hubert Kalbacher and Matthias Gross and Graeme Nicholson and Birgid Neumeister and James J. Mond and Andreas Peschel},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={243-245}
}
Colonization of the anterior nares in ∼37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S… CONTINUE READING
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